Title : Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers.

Pub. Date : 2002 Aug 1

PMID : 12151554






4 Functional Relationships(s)
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1 The content and evoked release of CGRP were significantly increased in tissues from morphine-exposed rats at 7, but not 1, days after implantation. Morphine calcitonin-related polypeptide alpha Rattus norvegicus
2 Enhanced evoked release of CGRP from morphine-pelleted rats was blocked by dynorphin antiserum or by previous lesions of the DLF. Morphine calcitonin-related polypeptide alpha Rattus norvegicus
3 Sustained morphine induces plasticity in both primary afferents and spinal cord, including increased CGRP and dynorphin content. Morphine calcitonin-related polypeptide alpha Rattus norvegicus
4 Morphine-induced elevation of spinal dynorphin content depends on descending influences and enhances stimulated CGRP release. Morphine calcitonin-related polypeptide alpha Rattus norvegicus