Pub. Date : 2002 Aug 15
PMID : 12149216
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In transcriptional coactivation assays, oxidized EPA potently activated the peroxisome proliferator-activated receptor alpha (PPAR alpha), a member of the nuclear receptor family. | Eicosapentaenoic Acid | peroxisome proliferator activated receptor alpha | Mus musculus |
| 2 | This occurred via a PPAR alpha-dependent mechanism because oxidized EPA had no such effect in LPS-treated PPAR alpha-deficient mice. | Eicosapentaenoic Acid | peroxisome proliferator activated receptor alpha | Mus musculus |
| 3 | Therefore, the beneficial effects of omega-3 fatty acids may be explained by a PPAR alpha-mediated anti-inflammatory effect of oxidized EPA. | Eicosapentaenoic Acid | peroxisome proliferator activated receptor alpha | Mus musculus |