Title : AT(1)-receptor blockade and the kidney: importance of non-ACE pathways in health and disease.

Pub. Date : 2002 Aug

PMID : 12140730






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1 Activation of the renin-angiotensin system is increased in diabetic patients, and comparison of the renal vascular responses to captopril and candesartan shows a strong correlation between the effects of ACE inhibition and AT(1)-receptor blockade, indicating that the deleterious effects of renin-angiotensin system activation in diabetes are mediated largely through angiotensin II. candesartan renin Homo sapiens