Title : Insulin-dependent activation of endothelial nitric oxide synthase is impaired by O-linked glycosylation modification of signaling proteins in human coronary endothelial cells.

Pub. Date : 2002 Jul 23

PMID : 12135947






2 Functional Relationships(s)
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1 Both in vivo and in vitro phosphorylation of endothelial nitric oxide synthase (eNOS) by Akt were reduced by hyperglycemia and hexosamine activation. Hexosamines AKT serine/threonine kinase 1 Homo sapiens
2 CONCLUSIONS: Our data show that hyperglycemia, through the hexosamine pathway, impairs activation of the IR/IRS/PI3-K/Akt pathway, resulting in deregulation of eNOS activity. Hexosamines AKT serine/threonine kinase 1 Homo sapiens