Title : Isoform-selective interaction of cyclooxygenase-2 with indomethacin amides studied by real-time fluorescence, inhibition kinetics, and site-directed mutagenesis.

Pub. Date : 2002 Jul 30

PMID : 12135387






2 Functional Relationships(s)
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1 Conversion of carboxylate-containing nonsteroidal antiinflammatory drugs, such as indomethacin, to esters or amides provides potent and selective inhibitors of cyclooxygenase-2 (COX-2) [Kalgutkar et al. Esters prostaglandin-endoperoxide synthase 2 Homo sapiens
2 Conversion of carboxylate-containing nonsteroidal antiinflammatory drugs, such as indomethacin, to esters or amides provides potent and selective inhibitors of cyclooxygenase-2 (COX-2) [Kalgutkar et al. Esters prostaglandin-endoperoxide synthase 2 Homo sapiens