Pub. Date : 2002 Aug
PMID : 12130704
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We used primary cultures of human hepatocytes from 15 subjects to assess the inducibility of CYP2C enzyme expression by prototypical inducer agents, including rifampicin, dexamethasone, and phenobarbital. | Phenobarbital | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |
| 2 | Phenobarbital (100 microM) was a powerful inducer of CYP2C9 (850%) and CYP2C19 (735%) mRNA content, and also increased CYP2C8 (610%) and CYP3A4 (205%) transcripts. | Phenobarbital | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |
| 3 | Our results show that CYP2C enzyme expression in human hepatocytes is highly inducible by rifampicin, dexamethasone, and phenobarbital. | Phenobarbital | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |