Title : Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures.

Pub. Date : 2002 Aug

PMID : 12124311






3 Functional Relationships(s)
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1 As tenofovir DF is a substrate for P-glycoprotein (P-gp)-related efflux carriers in the Caco-2 model, the modulatory effect of the ester mixtures was studied on the functionality of P-gp using cyclosporin A (CsA) as a model substrate. Tenofovir ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
2 As tenofovir DF is a substrate for P-glycoprotein (P-gp)-related efflux carriers in the Caco-2 model, the modulatory effect of the ester mixtures was studied on the functionality of P-gp using cyclosporin A (CsA) as a model substrate. Tenofovir ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
3 As tenofovir DF is a substrate for P-glycoprotein (P-gp)-related efflux carriers in the Caco-2 model, the modulatory effect of the ester mixtures was studied on the functionality of P-gp using cyclosporin A (CsA) as a model substrate. Tenofovir ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus