Pub. Date : 2002 Aug 1
PMID : 12118064
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Downregulation of protein kinase Calpha (PKCalpha) following long-term exposure to phorbol esters such as TPA is traffic dependent and involves delivery of the active, membrane-associated PKCalpha to endosomes. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
2 | Downregulation of protein kinase Calpha (PKCalpha) following long-term exposure to phorbol esters such as TPA is traffic dependent and involves delivery of the active, membrane-associated PKCalpha to endosomes. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
3 | Downregulation of protein kinase Calpha (PKCalpha) following long-term exposure to phorbol esters such as TPA is traffic dependent and involves delivery of the active, membrane-associated PKCalpha to endosomes. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
4 | In this study, we show that synaptotagmin II (Syt II), a member of the Syt family of proteins, is required for TPA-induced degradation of PKCalpha. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
5 | We demonstrate that in TPA-treated RBL cells, PKCalpha travels from the cytosol to the plasma membrane, where it is delivered to early endosomes on its route to degradation. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
6 | By contrast, in TPA-treated RBL-Syt II(-) cells, PKCalpha is diverted to recycling endosomes and remains distributed between the plasma membrane and the perinuclear recycling endocytic compartment. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |