Title : Suppression of Synaptotagmin II restrains phorbolester-induced downregulation of protein kinase Calpha by diverting the kinase from a degradative pathway to the recycling endocytic compartment.

Pub. Date : 2002 Aug 1

PMID : 12118064






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Downregulation of protein kinase Calpha (PKCalpha) following long-term exposure to phorbol esters such as TPA is traffic dependent and involves delivery of the active, membrane-associated PKCalpha to endosomes. Tetradecanoylphorbol Acetate protein kinase C, alpha Rattus norvegicus
2 Downregulation of protein kinase Calpha (PKCalpha) following long-term exposure to phorbol esters such as TPA is traffic dependent and involves delivery of the active, membrane-associated PKCalpha to endosomes. Tetradecanoylphorbol Acetate protein kinase C, alpha Rattus norvegicus
3 Downregulation of protein kinase Calpha (PKCalpha) following long-term exposure to phorbol esters such as TPA is traffic dependent and involves delivery of the active, membrane-associated PKCalpha to endosomes. Tetradecanoylphorbol Acetate protein kinase C, alpha Rattus norvegicus
4 In this study, we show that synaptotagmin II (Syt II), a member of the Syt family of proteins, is required for TPA-induced degradation of PKCalpha. Tetradecanoylphorbol Acetate protein kinase C, alpha Rattus norvegicus
5 We demonstrate that in TPA-treated RBL cells, PKCalpha travels from the cytosol to the plasma membrane, where it is delivered to early endosomes on its route to degradation. Tetradecanoylphorbol Acetate protein kinase C, alpha Rattus norvegicus
6 By contrast, in TPA-treated RBL-Syt II(-) cells, PKCalpha is diverted to recycling endosomes and remains distributed between the plasma membrane and the perinuclear recycling endocytic compartment. Tetradecanoylphorbol Acetate protein kinase C, alpha Rattus norvegicus