Pub. Date : 2002 Jun 10
PMID : 12115498
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we analyzed the effects of hypoxia, a common feature of solid tumors and a major drive to tumor angiogenesis, and of PA, a tryptophan catabolite produced under inflammatory conditions and endowed with several biologic properties, on the production of the angiogenic activator VEGF by advanced-stage human NB cell lines. | Protactinium | vascular endothelial growth factor A | Homo sapiens |
| 2 | VEGF upregulation by PA involved iron chelation because iron sulfate prevented this effect whereas the iron-chelating agent DFX induced VEGF production. | Protactinium | vascular endothelial growth factor A | Homo sapiens |
| 3 | Moreover, Flp exerted similar inhibitory activity on VEGF induction by PA or DFX, suggesting that this compound targets an essential step in the signaling pathway that leads to VEGF expression. | Protactinium | vascular endothelial growth factor A | Homo sapiens |