Title : Identification of the N-terminal functional domains of Cdk5 by molecular truncation and computer modeling.

Pub. Date : 2002 Aug 15

PMID : 12112670






3 Functional Relationships(s)
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1 A three-dimensional computer model of Cdk5-p25-ATP has been generated previously [Chou et al., Biochem Biophys Res Commun 1999;259:420-428], providing a structural basis for the study of the mechanisms of Cdk5 activation. Adenosine Triphosphate cyclin dependent kinase 5 Homo sapiens
2 A three-dimensional computer model of Cdk5-p25-ATP has been generated previously [Chou et al., Biochem Biophys Res Commun 1999;259:420-428], providing a structural basis for the study of the mechanisms of Cdk5 activation. Adenosine Triphosphate cyclin dependent kinase 5 Homo sapiens
3 To assess the predicted ATP and p25 binding domains at the N-terminal of Cdk5, two mutants of Cdk5 were prepared in which amino acids 9-15 (Delta9-15) or 9-47 (Delta9-47) were deleted. Adenosine Triphosphate cyclin dependent kinase 5 Homo sapiens