Pub. Date : 2002
PMID : 12097830
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The anti-platelet agent, ticlopidine, upregulates interleukin-1-Beta-stimulated nitric oxide production in cultured rat vascular smooth muscle cells. | Ticlopidine | interleukin 1 beta | Rattus norvegicus |
| 2 | RESULTS: Ticlopidine enhanced interleukin-1beta (IL-1beta)-induced nitrite production in a dose- and time-dependent manner. | Ticlopidine | interleukin 1 beta | Rattus norvegicus |
| 3 | RESULTS: Ticlopidine enhanced interleukin-1beta (IL-1beta)-induced nitrite production in a dose- and time-dependent manner. | Ticlopidine | interleukin 1 beta | Rattus norvegicus |
| 4 | IL-1beta alone stimulated both intracellular cAMP and cGMP contents, and the addition of ticlopidine further enhanced their contents. | Ticlopidine | interleukin 1 beta | Rattus norvegicus |
| 5 | KT 5720, a selective inhibitor of protein kinase A, but not KT 5823, a selective inhibitor of protein kinase G, abolished the enhancement of IL-1beta-induced nitrite production by ticlopidine. | Ticlopidine | interleukin 1 beta | Rattus norvegicus |
| 6 | CONCLUSION: We concluded that ticlopidine enhanced the IL-1beta-induced NO production via cAMP and subsequent activation of protein kinase A in cultured rat VSMC. | Ticlopidine | interleukin 1 beta | Rattus norvegicus |