Pub. Date : 2002 Jul 1
PMID : 12097302
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, this agent also inhibits the generation of reactive oxygen species (ROS) and the c-Jun NH(2)-terminal kinase (JNK) pathway, and because many chemotherapeutic drugs generate ROS and activate JNK in the course of inducing apoptosis, we considered the possibility that curcumin might antagonize their antitumor efficacy. | Curcumin | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | However, this agent also inhibits the generation of reactive oxygen species (ROS) and the c-Jun NH(2)-terminal kinase (JNK) pathway, and because many chemotherapeutic drugs generate ROS and activate JNK in the course of inducing apoptosis, we considered the possibility that curcumin might antagonize their antitumor efficacy. | Curcumin | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Under these conditions, curcumin exhibited antioxidant properties and inhibited both JNK activation and mitochondrial release of cytochrome c in a concentration-dependent manner. | Curcumin | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | These findings support the hypothesis that dietary curcumin can inhibit chemotherapy-induced apoptosis through inhibition of ROS generation and blockade of JNK function, and suggest that additional studies are needed to determine whether breast cancer patients undergoing chemotherapy should avoid curcumin supplementation, and possibly even limit their exposure to curcumin-containing foods. | Curcumin | mitogen-activated protein kinase 8 | Homo sapiens |