Title : Contribution of basic residues of the A helix of heparin cofactor II to heparin- or dermatan sulfate-mediated thrombin inhibition.

Pub. Date : 2002 Jul 3

PMID : 12095635






4 Functional Relationships(s)
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1 Contribution of basic residues of the A helix of heparin cofactor II to heparin- or dermatan sulfate-mediated thrombin inhibition. Dermatan Sulfate serpin family D member 1 Homo sapiens
2 Inhibition of thrombin by heparin cofactor II (HCII) is accelerated 1000-fold by heparin or dermatan sulfate. Dermatan Sulfate serpin family D member 1 Homo sapiens
3 Inhibition of thrombin by heparin cofactor II (HCII) is accelerated 1000-fold by heparin or dermatan sulfate. Dermatan Sulfate serpin family D member 1 Homo sapiens
4 These results provide evidence that basic residues of the A helix of HCII (Lys(101) and Arg(106)) are necessary for heparin- or dermatan sulfate-accelerated thrombin inhibition. Dermatan Sulfate serpin family D member 1 Homo sapiens