Pub. Date : 2002 Sep 13
PMID : 12093808
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A minimal system of five purified proteins, hsp90, hsp70, Hop, hsp40, and p23, assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding cleft to access by steroid. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | A minimal system of five purified proteins, hsp90, hsp70, Hop, hsp40, and p23, assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding cleft to access by steroid. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 3 | A minimal system of five purified proteins, hsp90, hsp70, Hop, hsp40, and p23, assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding cleft to access by steroid. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 4 | A minimal system of five purified proteins, hsp90, hsp70, Hop, hsp40, and p23, assembles glucocorticoid receptor (GR).hsp90 heterocomplexes and causes the simultaneous opening of the steroid binding cleft to access by steroid. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 5 | The rate-limiting step is the ATP-dependent opening of the steroid binding cleft after hsp90 binding. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 6 | The reported specific inhibitors of the C-terminal ATP site on hsp90 inhibit the generation of steroid binding, but they have other effects in this multiprotein system that could explain the inhibition. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |