Title : In vitro induction of cytochrome P450 2B1- and 3A1-mRNA and enzyme immunostaining in cryopreserved precision-cut rat liver slices.

Pub. Date : 2002 Jul 15

PMID : 12093615






1 Functional Relationships(s)
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1 Exposure to 1 microM pregnenolone 16 alpha-carbonitrile enhanced CYP3A1-mRNA expression by more than 30-fold within 24 h. This is in the same range, although with higher variability, as detected with fresh liver slices. Pregnenolone cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus