Title : Prostaglandin-E2 enhances EPO-mediated STAT5 transcriptional activity by serine phosphorylation of CREB.

Pub. Date : 2002 Jul 15

PMID : 12091337






3 Functional Relationships(s)
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1 Activation of the cAMP pathway resulted in cAMP-response element binding protein (CREB) phosphorylation, which was sustained in the presence of EPO plus PGE2 and transient on EPO stimulation alone. Bucladesine cAMP responsive element binding protein 1 Homo sapiens
2 Activation of the cAMP pathway resulted in cAMP-response element binding protein (CREB) phosphorylation, which was sustained in the presence of EPO plus PGE2 and transient on EPO stimulation alone. Bucladesine cAMP responsive element binding protein 1 Homo sapiens
3 In summary, these studies demonstrate that PGE2 enhancement of EPO-induced STAT5 transactivation is mediated by the cAMP/PKA/CREB pathway. Bucladesine cAMP responsive element binding protein 1 Homo sapiens