Pub. Date : 2002 Sep 6
PMID : 12087097
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Treatment of SW626 cells with paclitaxel activates Akt and ERK with different time frames. | Paclitaxel | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Interference with the ERK cascade by treatment with an MEK inhibitor, PD98059, in SW626 cells also caused decreased cell viability following treatment with paclitaxel. | Paclitaxel | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Our findings suggest that paclitaxel induces the phosphorylation of BAD Ser-112 via the ERK cascade, and the phosphorylation of both BAD Ser-136 and Raf-1 Ser-259 via the PI-3K-Akt cascade, and that inhibition of either of these cascades sensitizes ovarian cancer cells to paclitaxel. | Paclitaxel | mitogen-activated protein kinase 1 | Homo sapiens |