Title : Immune changes in patients with advanced breast cancer undergoing chemotherapy with taxanes.

Pub. Date : 2002 Jul 1

PMID : 12085250






2 Functional Relationships(s)
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1 More specifically, docetaxel demonstrated a more pronounced effect on enhancing MLR, NK, LAK activity and IFN-gamma, IL-2, IL-6, and GM-CSF levels, as well as caused more potent reduction in IL-1 and TNF-alpha levels when compared to paclitaxel. Docetaxel interleukin 6 Homo sapiens
2 The present study indicates that patients responded to treatment of advanced breast cancer with single-agent paclitaxel or docetaxel leads to an increase in serum IFN-gamma, IL-2, IL-6, GM-CSF cytokine levels and enhancement of PBMC NK and LAK cell activity, while they both lead to a decrease of acute phase serum cytokine levels of IL-1 and TNF-alpha. Docetaxel interleukin 6 Homo sapiens