Pub. Date : 2002
PMID : 12083975
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Many antipsychotics, including perphenazine, zuclopenthixol, thioridazine, haloperidol and risperidone, are metabolised to a significant extent by the polymorphic cytochrome P450 (CYP) 2D6, which shows large interindividual variation in activity. | Haloperidol | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 2 | Significant relationships between CYP2D6 genotype and steady-state concentrations have been reported for perphenazine, zuclopenthixol, risperidone and haloperidol when used in monotherapy. | Haloperidol | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |