Title : p53 regulates Stat3 phosphorylation and DNA binding activity in human prostate cancer cells expressing constitutively active Stat3.

Pub. Date : 2002 May 2

PMID : 12082540






1 Functional Relationships(s)
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1 Our results demonstrate that expression of wt p53 but not mutant p53 significantly reduced tyrosine phosphorylation of Stat3 and inhibited Stat3 DNA binding activity in both DU145 and Tsu prostate cancer cell lines that express constitutively active Stat3. Tyrosine tumor protein p53 Homo sapiens