Title : Genetic polymorphisms of DNA repair and xenobiotic-metabolizing enzymes: role in mutagen sensitivity.

Pub. Date : 2002 Jun

PMID : 12082022






2 Functional Relationships(s)
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1 XRCC1 codon 280 polymorphism had a significant effect (P = 0.012) in predetermining whether the individual was classified as non-sensitive, sensitive or hypersensitive to bleomycin. Bleomycin X-ray repair cross complementing 1 Homo sapiens
2 Although based on relatively few individuals, our results suggest that bleomycin sensitivity is partially explained by genetic polymorphisms affecting DNA repair (XRCC1) and in vitro metabolism of bleomycin (BLHX). Bleomycin X-ray repair cross complementing 1 Homo sapiens