Title : Dual regulation of phospholipase D1 by protein kinase C alpha in vivo.

Pub. Date : 2002 Jun 28

PMID : 12074591






4 Functional Relationships(s)
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1 In G361 cell line, which lacks PKCalpha, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced PLD activation was potentiated by introducing PKCalpha by the adenovirus vector. Tetradecanoylphorbol Acetate glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
2 In G361 cell line, which lacks PKCalpha, 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced PLD activation was potentiated by introducing PKCalpha by the adenovirus vector. Tetradecanoylphorbol Acetate glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
3 The kinase-negative PKCalpha elevated TPA-induced PLD activity less significantly than the wild type. Tetradecanoylphorbol Acetate glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
4 Expression of PKCbetaII and the kinase-negative PKCbetaII enhanced TPA-stimulated PLD activity moderately in MeWo cell line, in which PKCbetaII is absent. Tetradecanoylphorbol Acetate glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens