Title : Clinically relevant aminoglycosides can suppress disease-associated premature stop mutations in the IDUA and P53 cDNAs in a mammalian translation system.

Pub. Date : 2002 Jun

PMID : 12072912






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Clinically relevant aminoglycosides can suppress disease-associated premature stop mutations in the IDUA and P53 cDNAs in a mammalian translation system. Aminoglycosides tumor protein p53 Homo sapiens
2 Experiments with mammalian cDNAs confirmed these results and demonstrated that these aminoglycosides can also suppress disease-associated premature stop mutations previously identified in the IDUA gene (responsible for the lysosomal storage disease mucopolysaccharidosis I) and the P53 gene (associated with many forms of cancer). Aminoglycosides tumor protein p53 Homo sapiens