Title : Introduction of the most common cystic fibrosis mutation (Delta F508) into human P-glycoprotein disrupts packing of the transmembrane segments.

Pub. Date : 2002 Aug 2

PMID : 12070134






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Deleting Phe(508) in the P-gp/CFTR chimera, however, caused defective processing of the mutant protein and no detectable cross-linking between TM4 or TM5 and TM12. Phenylalanine ATP binding cassette subfamily B member 1 Homo sapiens