Title : Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene.

Pub. Date : 2002 Jun 15

PMID : 12067980






3 Functional Relationships(s)
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1 Examination of the MDR1 gene identified a binding site for hypoxia inducible factor-1 (HIF-1), and inhibition of HIF-1 expression by antisense oligonucleotides resulted in significant inhibition of hypoxia-inducible MDR1 expression and a nearly complete loss of basal MDR1 expression. Oligonucleotides ATP binding cassette subfamily B member 1 Homo sapiens
2 Examination of the MDR1 gene identified a binding site for hypoxia inducible factor-1 (HIF-1), and inhibition of HIF-1 expression by antisense oligonucleotides resulted in significant inhibition of hypoxia-inducible MDR1 expression and a nearly complete loss of basal MDR1 expression. Oligonucleotides ATP binding cassette subfamily B member 1 Homo sapiens
3 Examination of the MDR1 gene identified a binding site for hypoxia inducible factor-1 (HIF-1), and inhibition of HIF-1 expression by antisense oligonucleotides resulted in significant inhibition of hypoxia-inducible MDR1 expression and a nearly complete loss of basal MDR1 expression. Oligonucleotides ATP binding cassette subfamily B member 1 Homo sapiens