Title : Interference by toxic metal ions with zinc-dependent proteins involved in maintaining genomic stability.

Pub. Date : 2002 Aug

PMID : 12067581






2 Functional Relationships(s)
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1 Regarding the mammalian XPA protein involved in the recognition of DNA lesions during nucleotide excision repair, its DNA-binding capacity was diminished by Cd(II), Cu(II), Ni(II) and Co(II), while Hg(II), Pb(II) and As(III) were ineffective. as(iii) mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Finally, the H(2)O(2)-induced activation of the poly(ADP-ribose)polymerase (PARP) involved in DNA strand break detection and apoptosis was greatly reduced by Cd(II), Co(II), Ni(II) and As(III). as(iii) mitochondrially encoded cytochrome c oxidase II Homo sapiens