Title : Reactive oxygen species generated by PAH o-quinones cause change-in-function mutations in p53.

Pub. Date : 2002 Jun

PMID : 12067251






1 Functional Relationships(s)
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1 Treatment of p53 cDNA with micromolar concentrations of (+/-)-anti-7,8-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydro-benzo[a]pyrene, (anti-BPDE, an ultimate carcinogen) or sub-micromolar concentrations of BP-7,8-dione in the presence of redox-cycling conditions (NADPH and CuCl(2)) also caused p53 mutations in a dose-dependent manner. cupric chloride tumor protein p53 Homo sapiens