Title : Induction of p53 accumulation by Moloney murine leukemia virus-ts1 infection in astrocytes via activation of extracellular signal-regulated kinases 1/2.

Pub. Date : 2002 Jun

PMID : 12065679






2 Functional Relationships(s)
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1 In these studies using mitogen-activated protein kinase inhibitors, infection-induced increases in the p53 level were partially blocked by PD98059, a synthetic inhibitor of MEK1 that is the immediate upstream kinase of extracellular signal-regulated kinases 1/2 (ERK1/2), but not by SB202190, a potent p38 kinase inhibitor. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one tumor protein p53 Homo sapiens
2 Furthermore, treatment with PD98059 significantly decreased the level of p21 protein, a p53-dependent gene product. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one tumor protein p53 Homo sapiens