Pub. Date : 2002 Aug 16
PMID : 12065594
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. | Etoposide | caspase 2 | Homo sapiens |
| 2 | We demonstrate here a role for caspase-2 in etoposide-induced cytochrome c release. | Etoposide | caspase 2 | Homo sapiens |
| 3 | Experiments performed using a reconstituted cell-free system indicate that etoposide-induced cytochrome c release by way of caspase-2 occurs independently of cytosolic factors, suggesting that the nuclear pool of pro-caspase-2 is critical to this process. | Etoposide | caspase 2 | Homo sapiens |
| 4 | Experiments performed using a reconstituted cell-free system indicate that etoposide-induced cytochrome c release by way of caspase-2 occurs independently of cytosolic factors, suggesting that the nuclear pool of pro-caspase-2 is critical to this process. | Etoposide | caspase 2 | Homo sapiens |
| 5 | Taken together, our data indicate that caspase-2 provides an important link between etoposide-induced DNA damage and the engagement of the mitochondrial apoptotic pathway. | Etoposide | caspase 2 | Homo sapiens |