Title : The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

Pub. Date : 2002 Jun

PMID : 12062094






2 Functional Relationships(s)
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1 In the search for neuroprotective factors in Huntington"s disease, we found that insulin growth factor 1 via activation of the serine/threonine kinase Akt/PKB is able to inhibit neuronal death specifically induced by mutant huntingtin containing an expanded polyglutamine stretch. polyglutamine AKT serine/threonine kinase 1 Homo sapiens
2 In the search for neuroprotective factors in Huntington"s disease, we found that insulin growth factor 1 via activation of the serine/threonine kinase Akt/PKB is able to inhibit neuronal death specifically induced by mutant huntingtin containing an expanded polyglutamine stretch. polyglutamine AKT serine/threonine kinase 1 Homo sapiens