Title : The histone deacetylase inhibitor sodium butyrate interacts synergistically with phorbol myristate acetate (PMA) to induce mitochondrial damage and apoptosis in human myeloid leukemia cells through a tumor necrosis factor-alpha-mediated process.

Pub. Date : 2002 Jul 1

PMID : 12061815






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Exposure of U937 cells to 1 mM SB and 1 nM PMA (24 h) markedly induced caspase activation and apoptosis, events accompanied by impaired differentiation induction (e.g., reduced plastic adherence and diminished expression of CD11b) as well as reduced clonogenic survival. Tetradecanoylphorbol Acetate integrin subunit alpha M Homo sapiens