Pub. Date : 2002 Jun 10
PMID : 12058016
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1. | polyglutamine | prion domain-containing protein RNQ1 | Saccharomyces cerevisiae S288C |
| 2 | We screened a set of deletions of nonessential genes coding for known prions and related proteins and found that deletion of the RNQ1 gene specifically suppressed aggregation and toxicity of polyQ. | polyglutamine | prion domain-containing protein RNQ1 | Saccharomyces cerevisiae S288C |
| 3 | Curing of the prion form of Rnq1 from wild-type cells dramatically suppressed both aggregation and toxicity of polyQ. | polyglutamine | prion domain-containing protein RNQ1 | Saccharomyces cerevisiae S288C |