Title : JDP2, a repressor of AP-1, recruits a histone deacetylase 3 complex to inhibit the retinoic acid-induced differentiation of F9 cells.

Pub. Date : 2002 Jul

PMID : 12052888






3 Functional Relationships(s)
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1 Up-regulation of the c-jun gene is a critical event in the retinoic acid (RA)-mediated differentiation of embryonal carcinoma F9 cells. Tretinoin Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Up-regulation of the c-jun gene is a critical event in the retinoic acid (RA)-mediated differentiation of embryonal carcinoma F9 cells. Tretinoin Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
3 Moreover, chromatin immunoprecipitation assays showed that the JDP2/HDAC3 complex, which binds to the differentiation response element within the c-jun promoter in undifferentiated F9 cells, was replaced by the p300 complex in response to RA, with an accompanying change in the histone acetylation status of the chromatin, the initiation of transcription of the c-jun gene, and the subsequent differentiation of F9 cells. Tretinoin Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens