Title : A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance.

Pub. Date : 2002 Jun

PMID : 12042670






1 Functional Relationships(s)
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1 In contrast to the reduced LTC4 and oestrone sulphate transport, stably transfected HeLa cells expressing Arg433Ser mutant MRP1 were 2.1-fold more resistant to doxorubicin than cells expressing wild-type MRP1, while resistance to VP-16 and vincristine was unchanged. Etoposide ATP binding cassette subfamily C member 1 Homo sapiens