Title : Inactivation and degradation of O(6)-alkylguanine-DNA alkyltransferase after reaction with nitric oxide.

Pub. Date : 2002 Jun 1

PMID : 12036910






1 Functional Relationships(s)
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1 Although the S-nitrosylcysteine adduct in hAGT is readily reversible by reaction with other cellular thiols, the formation of S-nitrosocysteine at Cys-145 was found to lead to the rapid degradation of the hAGT protein in vivo. Sulfhydryl Compounds angiotensinogen Homo sapiens