Title : Regulation of constitutive and induced NF-kappaB activation in malignant melanoma cells by capsaicin modulates interleukin-8 production and cell proliferation.

Pub. Date : 2002 Apr

PMID : 12034025






6 Functional Relationships(s)
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1 Regulation of constitutive and induced NF-kappaB activation in malignant melanoma cells by capsaicin modulates interleukin-8 production and cell proliferation. Capsaicin C-X-C motif chemokine ligand 8 Homo sapiens
2 Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells. Capsaicin C-X-C motif chemokine ligand 8 Homo sapiens
3 Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells. Capsaicin C-X-C motif chemokine ligand 8 Homo sapiens
4 The inhibition of IL-8 expression was dependent on the concentration of capsaicin and duration of treatment. Capsaicin C-X-C motif chemokine ligand 8 Homo sapiens
5 Treatment of melanoma cells with capsaicin inhibited activation of constitutive and IL-1beta-induced NF-kappaB, but not AP-1, leading to inhibition of IL-8 expression. Capsaicin C-X-C motif chemokine ligand 8 Homo sapiens
6 Further, downregulation of IL-8 expression in capsaicin-treated melanoma cells resulted in inhibition of in vitro cell proliferation. Capsaicin C-X-C motif chemokine ligand 8 Homo sapiens