Pub. Date : 2002 Jun
PMID : 12021185
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Iodide accumulation increased after 2-h exposure to 5 IU/ml hCG, to 6-fold over the basal level after 8 h. This effect was reproduced using forskolin, the cAMP analog (Bu)(2)-cAMP, and phorbol acetate. | Iodides | chorionic gonadotropin subunit beta 5 | Homo sapiens |
| 2 | Functional analysis clearly showed that Jar cells are able to concentrate iodide in presence of hCG. | Iodides | chorionic gonadotropin subunit beta 5 | Homo sapiens |
| 3 | In conclusion, our data demonstrate that 1) NIS is expressed in JAr cells; 2) iodide transport in JAr cells is regulated by hCG and by cAMP-dependent and -independent mechanisms; 3) the stimulation of iodide uptake is due to an increase in both NIS mRNA and protein levels; and 4) JAr cells may represent an excellent in vitro model suitable to analyze the molecular mechanisms involved in iodide transport from mother to fetus. | Iodides | chorionic gonadotropin subunit beta 5 | Homo sapiens |