Pub. Date : 2002 Apr 30
PMID : 12018840
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Signaling and function of caspase and c-jun N-terminal kinase in cisplatin-induced apoptosis. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Treatment of Jurkat T-cells with cisplatin induced cell death with DNA fragmentation and activation of caspase and JNK. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | On the other hand, cisplatin induced the JNK activation in both the wild-type and JB-6 cells, and the caspase-3 inhibitor Z-DEVD-fmk did not inhibit this activation. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | The JNK overexpression resulted in a higher JNK activity, AP-1 DNA binding activity, and metallothionein expression than the empty vector-transfected cells following cisplatin treatment. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | These data suggest that the cisplatin-induced apoptotic signal is initiated by the caspase-8-independent cytochrome c release, and the JNK activation protects cells from cisplatin-induced apoptosis via the metallothionein expression. | Cisplatin | mitogen-activated protein kinase 8 | Homo sapiens |