Pub. Date : 2002 Jan
PMID : 12018409
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Isosteric replacement of A3 Val of porcine insulin by allo-Thr. | Threonine | insulin | Homo sapiens |
| 2 | When A3 Val was replaced by Thr, which is hydrophilic but isosteric with Val, substantial insulin activity was retained. | Threonine | insulin | Homo sapiens |
| 3 | Here we report the replacement of A3 Val of porcine insulin by the unnatural allo-Thr. | Threonine | insulin | Homo sapiens |
| 4 | The in vivo biological activity of A3 allo-Thr insulin is similar to that of A3 Thr insulin or native insulin, but its receptor binding activity is 7.6% instead of 50% for A3 Thr insulin, indicating that at the A3 position the hydrophilic OH group of Thr could be more tolerated in receptor binding than the OH group of allo-Thr. | Threonine | insulin | Homo sapiens |
| 5 | The retention of insulin activity by substituting A3 Val with the unnatural isosteric allo-Thr demonstrates again the importance of isosteric interaction in the binding of insulin with its receptor. | Threonine | insulin | Homo sapiens |