Pub. Date : 2002
PMID : 12017551
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Physiological effects of progesterone are mediated by interaction of the hormone with specific intracellular progesterone receptors (PRs) that are expressed as two protein isoforms, PR-A and PR-B. | Progesterone | S100 calcium binding protein A6 (calcyclin) | Mus musculus |
| 2 | First, analysis of the structural and functional relationships of each isoform using in vitro systems has generated compelling evidence to support the conclusion that PR-A and PR-B have different transcription activation properties when liganded to progesterone. | Progesterone | S100 calcium binding protein A6 (calcyclin) | Mus musculus |
| 3 | Selective ablation of PR-A and PR-B proteins in mice using these technologies has allowed us to address the spatiotemporal expression and contribution of the individual PR isoforms to the pleiotropic reproductive activities of progesterone. | Progesterone | S100 calcium binding protein A6 (calcyclin) | Mus musculus |
| 4 | Analysis of the phenotypic consequences of these mutations on female reproductive function has provided proof of concept that the distinct transcriptional responses to PR-A and PR-B observed in cell-based transactivation assays are, indeed, reflected in an ability of the individual isoforms to elicit distinct, physiological responses to progesterone. | Progesterone | S100 calcium binding protein A6 (calcyclin) | Mus musculus |
| 5 | Thus, PR-A is both necessary and sufficient to elicit the progesterone-dependent reproductive responses necessary for female fertility, while PR-B is required to elicit normal proliferative responses of the mammary gland to progesterone. | Progesterone | S100 calcium binding protein A6 (calcyclin) | Mus musculus |