Title : Reproductive functions of progesterone receptors.

Pub. Date : 2002

PMID : 12017551






5 Functional Relationships(s)
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1 Physiological effects of progesterone are mediated by interaction of the hormone with specific intracellular progesterone receptors (PRs) that are expressed as two protein isoforms, PR-A and PR-B. Progesterone progesterone receptor Mus musculus
2 First, analysis of the structural and functional relationships of each isoform using in vitro systems has generated compelling evidence to support the conclusion that PR-A and PR-B have different transcription activation properties when liganded to progesterone. Progesterone progesterone receptor Mus musculus
3 Selective ablation of PR-A and PR-B proteins in mice using these technologies has allowed us to address the spatiotemporal expression and contribution of the individual PR isoforms to the pleiotropic reproductive activities of progesterone. Progesterone progesterone receptor Mus musculus
4 Analysis of the phenotypic consequences of these mutations on female reproductive function has provided proof of concept that the distinct transcriptional responses to PR-A and PR-B observed in cell-based transactivation assays are, indeed, reflected in an ability of the individual isoforms to elicit distinct, physiological responses to progesterone. Progesterone progesterone receptor Mus musculus
5 These tissue-selective activities of PR-B are due to this isoform"s ability to regulate a subset of progesterone-responsive target genes in reproductive tissues rather than to differences in its spatiotemporal expression relative to the PR-A isoform. Progesterone progesterone receptor Mus musculus