Title : [New taxanes and epothilone derivatives in clinical trials].

Pub. Date : 2002 Apr

PMID : 12016034






1 Functional Relationships(s)
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1 Six new taxanes are currently in clinical trials: BMS 184476, BMS 188797, BMS 275183, IDN 5109/BAY 598862, RPR 109881A et RPR 116258 All these derivatives share the same feature which is a decreased recognition by Pgp-170, the product of the MDR1 gene. Taxoids ATP binding cassette subfamily B member 1 Homo sapiens