Title : Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases.

Pub. Date : 2002 May 14

PMID : 12011469






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We find parallel selectivity at a cellular level; acetaminophen inhibits PGHS activity with an IC(50) of 4.3 microM in interleukin (IL)-1 alpha-stimulated human umbilical vein endothelial cells, in contrast with an IC(50) of 1,870 microM for the platelet, with 2 microM arachidonic acid as substrate. Acetaminophen interleukin 1 alpha Homo sapiens