Title : Up-regulation of cyclooxygenase-2 expression and prostaglandin synthesis in endometrial stromal cells by malignant endometrial epithelial cells. A paracrine effect mediated by prostaglandin E2 and nuclear factor-kappa B.

Pub. Date : 2002 Jul 19

PMID : 12006564






3 Functional Relationships(s)
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1 Intriguingly, we found that PGE(2) was one of the major factors in MECM, which was responsible for up-regulating COX-2 expression in ESC. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 In conclusion, malignant endometrial epithelial cells secrete PGE(2) that induces COX-2 expression in normal endometrial stromal cells in a paracrine fashion through activation of transcription and stabilization of COX-2 mRNA. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 In conclusion, malignant endometrial epithelial cells secrete PGE(2) that induces COX-2 expression in normal endometrial stromal cells in a paracrine fashion through activation of transcription and stabilization of COX-2 mRNA. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens