Title : Effects of Cl- channel blockers on endothelin-1-induced proliferation of rat vascular smooth muscle cells.

Pub. Date : 2002 Mar 29

PMID : 12005183






2 Functional Relationships(s)
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1 Both nifedipine and SK&F96365 inhibited 10 nM ET-1-induced [3H]-thymidine incorporation into VSMC with the maximal inhibitory concentrations of 1 and 10 microM, respectively. Nifedipine endothelin 1 Rattus norvegicus
2 Pretreatment of VSMC with 1 microM nifedipine completely inhibited the DIDS effect on 10 nM ET-1-induced [3H]-thymidine incorporation into VSMC and sustained increase in [Ca2+]i, whereas pretreatment with 10 microM SK&F96365 did not completely block these effects of DIDS. Nifedipine endothelin 1 Rattus norvegicus