Title : Cyclooxygenase-1 and bicistronic cyclooxygenase-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction.

Pub. Date : 2002 Apr 23

PMID : 11997284






2 Functional Relationships(s)
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1 Adv-COX-1/PGIS infusion selectively augmented prostacyclin levels, with reduction of other eicosanoids in ischemic cortex and a significant reduction of infarct volume, even when the rAd was administered 5 hours after ischemia. Epoprostenol prostaglandin I2 synthase Rattus norvegicus
2 CONCLUSIONS: COX-1/PGIS and COX-1 gene transfer reduce cerebral infarct volume by augmenting prostacyclin and suppressing leukotriene productions. Epoprostenol prostaglandin I2 synthase Rattus norvegicus