Pub. Date : 2002 Jun
PMID : 11992116
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The vanilloid receptor-1 (VR1) is a heat-gated ion channel that is responsible for the burning sensation elicited by capsaicin. | Capsaicin | transient receptor potential cation channel subfamily V member 1 | Homo sapiens |
| 2 | The vanilloid receptor-1 (VR1) is a heat-gated ion channel that is responsible for the burning sensation elicited by capsaicin. | Capsaicin | transient receptor potential cation channel subfamily V member 1 | Homo sapiens |
| 3 | Ethanol potentiated the response of VR1 to capsaicin, protons and heat and lowered the threshold for heat activation of VR1 from approximately 42 degrees C to approximately 34 degrees C. This provides a likely mechanistic explanation for the ethanol-induced sensory responses that occur at body temperature and for the sensitivity of inflamed tissues to ethanol, such as might be found in esophagitis, neuralgia or wounds. | Capsaicin | transient receptor potential cation channel subfamily V member 1 | Homo sapiens |