Title : One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme.

Pub. Date : 2001 Nov

PMID : 11989624






1 Functional Relationships(s)
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1 The bound pteridine ring of folate (Fol I) from the crystal structure of R67 DHFR was used as the basis for docking the nicotinamide-ribose-Pi (NMN) moiety of NADPH. Folic Acid dihydrofolate reductase Homo sapiens