Title : A novel pathway for adrenergic stimulation of cAMP-response-element-binding protein (CREB) phosphorylation: mediation via alpha1-adrenoceptors and protein kinase C activation.

Pub. Date : 2002 May 15

PMID : 11988078






2 Functional Relationships(s)
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1 The increase in CREB phosphorylation coincided with increased expression of an artificial cAMP-response-element-containing reporter construct. Cyclic AMP cAMP responsive element binding protein 1 Mus musculus
2 We conclude that CREB phosphorylation in brown adipocytes is mediated not only through the classical beta-adrenergic/cAMP pathway but also through a novel alpha(1)-adrenergic/protein kinase C/CREB pathway, which has not been described previously in any tissue. Cyclic AMP cAMP responsive element binding protein 1 Mus musculus