Pub. Date : 2002 Apr
PMID : 11985663
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Endothelial cell and cAMP regulation of T-cell CD40 ligand: relevance of calcium/calmodulin-dependent kinase IV signalling. | Cyclic AMP | CD40 ligand | Homo sapiens |
| 2 | Because increased CD40L has been associated with myocardial infarction, effects of endothelial cells and cAMP with respect to CD40L regulation may be of clinical relevance. | Cyclic AMP | CD40 ligand | Homo sapiens |
| 3 | Although it has previously been recognized that human endothelial cells can increase T-cell CD40L, this is the first description of the difference in responses of naive and memory cells and the first demonstration of synergistic effects of endothelial cells and cAMP on CD40L regulation. | Cyclic AMP | CD40 ligand | Homo sapiens |
| 4 | Endothelial cell costimulation of CD40L was found to be dependent upon calcineurin activity while cAMP actions to increase CD40L were dependent upon CaMKIV. | Cyclic AMP | CD40 ligand | Homo sapiens |
| 5 | These data indicate that endothelial cell costimulation can interact with cAMP through calcium signalling pathways to synergistically enhance CD40L expression. | Cyclic AMP | CD40 ligand | Homo sapiens |